Benefits
Automated DNA quantification of ALL samples simultaneously
Generates clean fragments of a precise size range of interest
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Time and reagent saving
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Fast run time leading to decreased turnaround time
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Accurate DNA quantification
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Integration with automated library preparation platform
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Enriches fetal fraction by two-fold
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Allows for high-multiplexing in the future
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Allows for more consistent analysis, further reducing failure rate
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Reduce or eliminate the hassle and wasted time & expense of sequencing off-target fragments
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Lower pool concentrations needed (from only 100pM), decreasing failure rate
The Yourgene QS250, supplied by Yourgene Health performs:
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Fragment length analysis
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Accurate Library quantification
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Enrichment of DNA of interest
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All with a single piece of equipment
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Blood Borne VirusesHepatitis A Virus (HAV) Hepatitis E Virus (HEV) Parvovirus B19
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Enteric Viruses and BacteriaClostridium difficile EHEC Norovirus Rotavirus
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Human Adenovirus, Human Herpesvirus and PolyomavirusHuman adenovirus (ADV) Cytomegalovirus (CMV) Epstein-Barr Virus (EBV) Human Herpesvirus 6A and 6B (HHV-6) Herpes Simplex Virus 1 and 2 (HSV) Varicella-Zoster Virus (VZV) BK Virus (BKV) JC Virus (JCV)
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Respiratory Viruses, Bacteria and FungiHuman adenovirus (ADV) Enterovirus (ENV) and Rhinovirus (RHV) Human Influenza A and B and SwineFlu Middle East Respiratory Syndrome Coronavirus (MERS-CoV) Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Human Metapneumovirus A and B (hMPV) Human Parainfluenza Virus 1– 4 (PIV) Respiratory Syncytial Virus A and B (RSVA and RSVB) Bordetella pertussis and Bordetella parapertussis Pneumocystis jirovecii
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Tropical and other Viruses, Bacteria and ParasitesAHFV/KFDV CCHFV Chagas Chikungunya Dengue Ebolavirus Filovirus Lassa Virus Malaria Rift Valley Fever Trichomonas vaginalis WNV Yellow Fever Zika Virus
IONA® Nx, is a screening test that performs:
1. Whole genome analysis to measure the likelihood that a pregnant woman is carrying a fetus with:
Most common trisomies
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Trisomy 21 (Down’ Syndrome)
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Trisomy 18 (Edwards’ Syndrome)
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Trisomy 13 (Patau’s Syndrome)
Autosomal Aneuploidies (AAs)
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Additional trisomy across the whole-genome
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All monosomy across the whole-genome
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Sex Chromosome Aneuploidies (SCAs)
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45,X (Turner Syndrome)
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47,XXX (Trisomy X)
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47,XXY (Klinefelter’s Syndrome)
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47,XYY (Jacob’s Syndrome)
2. Fetal Sex Determination
Key Features of the IONA® Nx NIPT Workflow
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Advanced proprietary reagents and software technologies
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Simple process with minimum instrumentation capital expenditure, suppliers and contract services
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Designed to offer flexibility (automated or manual) and scalability to suit varying customer needs