Benefits
Automated DNA quantification of ALL samples simultaneously
Generates clean fragments of a precise size range of interest
-
Time and reagent saving
-
Fast run time leading to decreased turnaround time
-
Accurate DNA quantification
-
Integration with automated library preparation platform
-
Enriches fetal fraction by two-fold
-
Allows for high-multiplexing in the future
-
Allows for more consistent analysis, further reducing failure rate
-
Reduce or eliminate the hassle and wasted time & expense of sequencing off-target fragments
-
Lower pool concentrations needed (from only 100pM), decreasing failure rate
The Yourgene QS250, supplied by Yourgene Health performs:
-
Fragment length analysis
-
Accurate Library quantification
-
Enrichment of DNA of interest
-
All with a single piece of equipment
IONA® Nx, is a screening test that performs:
1. Whole genome analysis to measure the likelihood that a pregnant woman is carrying a fetus with:
Most common trisomies
-
Trisomy 21 (Down’ Syndrome)
-
Trisomy 18 (Edwards’ Syndrome)
-
Trisomy 13 (Patau’s Syndrome)
Autosomal Aneuploidies (AAs)
-
Additional trisomy across the whole-genome
-
All monosomy across the whole-genome
-
Sex Chromosome Aneuploidies (SCAs)
-
45,X (Turner Syndrome)
-
47,XXX (Trisomy X)
-
47,XXY (Klinefelter’s Syndrome)
-
47,XYY (Jacob’s Syndrome)
2. Fetal Sex Determination
Key Features of the IONA® Nx NIPT Workflow
-
Advanced proprietary reagents and software technologies
-
Simple process with minimum instrumentation capital expenditure, suppliers and contract services
-
Designed to offer flexibility (automated or manual) and scalability to suit varying customer needs